Professional and Linguistic Assessments Board (PLAB) Practice Exam

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Pseudogout is commonly linked to which endocrine disorder?

Hyperthyroidism
Hypothyroidism
Cushing's syndrome
Diabetes mellitus

The correct answer is: Hypothyroidism

Pseudogout, also known as calcium pyrophosphate dihydrate (CPPD) crystal arthritis, is frequently associated with conditions of altered calcium metabolism. Among the endocrine disorders, hypothyroidism is notably linked with the development of pseudogout. This connection arises because individuals with hypothyroidism may have changes in their calcium and phosphate balance, which can lead to the formation of CPPD crystals. The metabolism of connective tissues is affected by thyroid hormones, and insufficient levels can contribute to joint problems, including pseudogout. In contrast, while the other listed endocrine disorders may have their own series of complications, they do not have the same direct and established relationship with pseudogout as hypothyroidism does. Thus, the association of pseudogout with hypothyroidism is a recognized aspect of how metabolic and thyroid function can influence joint health.