Professional and Linguistic Assessments Board (PLAB) Practice Exam

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What class of drugs does '-gravir' belong to?

NRTIs
Integrase inhibitors
NNRTIs
Protease inhibitors

The correct answer is: Integrase inhibitors

The suffix '-gravir' indicates that these drugs are integrase inhibitors, which are a specific class of antiretroviral medications used primarily in the treatment of HIV. Integrase inhibitors work by blocking the integrase enzyme, which the HIV virus uses to insert its genetic material into the host cell's DNA. This mechanism of action prevents the virus from replicating and helps to control the infection effectively. Integrase inhibitors have become a critical component of modern HIV therapy due to their potency, usability (often in once-daily regimens), and favorable side effect profiles compared to some older classes of antiviral medications. Understanding drug classes and their mechanisms is essential for effective treatment strategies in managing HIV, hence the significance of recognizing '-gravir' as a marker for integrase inhibitors.