Professional and Linguistic Assessments Board (PLAB) Practice Exam

What is the first-line treatment for endometritis?

1. Clindamycin and gentamicin

2. Amoxicillin and clavulanate

3. Tetracycline and metronidazole

4. Azithromycin and doxycycline

The correct answer is: Clindamycin and gentamicin

The first-line treatment for endometritis is a combination of clindamycin and gentamicin. This regimen is chosen because it effectively targets the polymicrobial nature of the infection commonly associated with endometritis, which can occur after childbirth or miscarriage. Clindamycin is effective against anaerobic bacteria, while gentamicin covers aerobic gram-negative bacteria. This dual approach ensures comprehensive coverage and addresses the diverse bacterial flora that can lead to the infection. Other treatment regimens listed may not provide the same level of efficacy against the specific bacteria typically involved in endometritis. For instance, amoxicillin and clavulanate primarily target certain aerobic bacteria but might not adequately cover the full spectrum of anaerobic pathogens. Similarly, tetracycline and metronidazole and azithromycin and doxycycline do not have the same broad-spectrum effectiveness against the range of organisms causing endometritis. Thus, the combination of clindamycin and gentamicin remains the most appropriate choice for addressing this condition efficiently.