Professional and Linguistic Assessments Board (PLAB) Practice Exam

What is the primary condition associated with MEN 2b?

1. Pheochromocytoma, medullary carcinoma, neuroma

2. Parathyroid hyperplasia

3. Medullary carcinoma, thyroid cancer

4. Pancreatic islet cell tumor

The correct answer is: Pheochromocytoma, medullary carcinoma, neuroma

The primary condition associated with Multiple Endocrine Neoplasia type 2B (MEN 2B) is characterized by a distinct cluster of tumors and symptoms, which include pheochromocytoma, medullary thyroid carcinoma, and mucosal neuromas. Pheochromocytoma involves the adrenal glands producing excess catecholamines, leading to hypertension and other related symptoms. Medullary thyroid carcinoma arises from parafollicular C cells, which can cause elevated calcitonin levels and forms a significant aspect of the syndrome's risk profile. Mucosal neuromas are benign tumors affecting the nervous tissue, commonly present on the lips and in the oral cavity. The other choices listed represent conditions associated with different types of Multiple Endocrine Neoplasia or other endocrine disorders, but they do not encompass the hallmark triad linked specifically with MEN 2B. Parathyroid hyperplasia is more related to MEN 1 and 2A but not MEN 2B. Medullary carcinoma is indeed part of MEN 2B, but the choice does not consider pheochromocytoma and neuromas, which are equally defining features of the syndrome. Pancreatic islet cell tumors are typically associated with MEN