Professional and Linguistic Assessments Board (PLAB) Practice Exam

What is the recommended treatment for acute attacks of Crohn's disease?

1. Mesalamine

2. Infliximab

3. Oral corticosteroids (Prednisone)

4. Aminosalicylates

The correct answer is: Oral corticosteroids (Prednisone)

The recommended treatment for acute attacks of Crohn's disease typically involves the use of oral corticosteroids, such as Prednisone. During flare-ups, corticosteroids are effective in rapidly reducing inflammation in the gastrointestinal tract, helping to alleviate symptoms such as abdominal pain, diarrhea, and rectal bleeding. They work by suppressing the immune system's inflammatory response, which can be particularly beneficial in managing the acute symptoms associated with Crohn's disease. While other treatments, such as infliximab, are used to manage the condition in a broader sense, particularly for moderate to severe cases, they may not be the first line of treatment during an acute attack. Infliximab is a biologic therapy and is more often reserved for patients who do not adequately respond to corticosteroids or those with a severe disease course. Aminosalicylates and mesalamine are generally used for mild cases or maintenance of remission rather than as a primary treatment during acute exacerbations. Their role largely focuses on reducing inflammation in less severe situations, making them less suitable for addressing immediate and severe symptoms. Thus, oral corticosteroids remain the most effective option for managing acute attacks of Crohn's disease.