Professional and Linguistic Assessments Board (PLAB) Practice Exam

Which condition is commonly associated with anterior uveitis?

1. Rheumatoid arthritis

2. Ankylosing spondylitis

3. Systemic lupus erythematosus

4. Gout

The correct answer is: Ankylosing spondylitis

Anterior uveitis, also known as iritis, is commonly associated with ankylosing spondylitis, which is an inflammatory arthritis affecting the spine and large joints, often leading to pain and stiffness. The connection between ankylosing spondylitis and anterior uveitis is well established; many patients with this condition experience episodes of uveitis due to underlying autoimmune processes. The inflammation in ankylosing spondylitis can trigger a response in the eye, resulting in uveitis. It is particularly notable because this association is strong, and these patients are often screened for ocular symptoms due to this relationship. Conditions like rheumatoid arthritis and systemic lupus erythematosus can also be associated with eye issues, but they do not have the same established and direct link to anterior uveitis as ankylosing spondylitis does. Gout is primarily a crystal-induced arthropathy, and while it can lead to joint inflammation, it is less frequently connected with uveitis. Hence, the strongest link in the context of anterior uveitis is with ankylosing spondylitis.