Professional and Linguistic Assessments Board (PLAB) Practice Exam

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Which drug class does lorazepam belong to that is used in treating seizures?

Antidepressants
Stimulants
Benzodiazepines
Barbiturates

The correct answer is: Benzodiazepines

Lorazepam belongs to the class of drugs known as benzodiazepines. This class is well-established for its efficacy in treating various conditions, including anxiety and seizures. Benzodiazepines work by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA), which results in sedative, anxiolytic, and anticonvulsant properties. In the context of treating seizures, lorazepam is often used in emergency situations such as status epilepticus due to its rapid onset of action. Its ability to stabilize neuronal membranes helps in terminating seizure activity, making it a critical medication for acute seizure management. Recognizing the characteristics of lorazepam as a benzodiazepine clarifies why this option is the most appropriate among the choices provided. Other classes, such as antidepressants, stimulants, and barbiturates, have different mechanisms and indications that do not align directly with the emergency treatment of seizures.