Professional and Linguistic Assessments Board (PLAB) Practice Exam

Which medication is commonly used for treating neuropathic pain?

1. Amitriptyline

2. Duloxetine

3. Gabapentin

4. All of the above

The correct answer is: All of the above

The commonly used medications for treating neuropathic pain include amitriptyline, duloxetine, and gabapentin. Each of these drugs operates through different mechanisms to alleviate neuropathic pain, which often arises from nerve damage or dysfunction. Amitriptyline is a tricyclic antidepressant that influences neurotransmitters in the brain, particularly by increasing serotonin and norepinephrine levels. This action not only helps to manage depression but also has a significant analgesic effect, making it effective for neuropathic pain. Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that also enhances neurotransmitter levels to provide pain relief. It is particularly beneficial for conditions like fibromyalgia and diabetic neuropathy, where the modulation of pain pathways is critical. Gabapentin is an anticonvulsant that alters the way nerves send messages to the brain. By inhibiting excitatory neurotransmitters, it reduces the perception of pain and is often specifically prescribed for neuropathic pain conditions. Since each of these medications has established efficacy in treating neuropathic pain, the correct choice encompasses all three, affirming that they are all valid options in managing this type of discomfort.