Professional and Linguistic Assessments Board (PLAB) Practice Exam

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Which of the following medications is contraindicated in patients with a known allergy to aspirin?

  1. Clopidogrel

  2. Beta Blocker

  3. Statin

  4. Calcium Channel Blocker

The correct answer is: Clopidogrel

In patients with a known allergy to aspirin, clopidogrel is contraindicated because it can have similar effects on platelet function as aspirin. Both medications are antiplatelet agents, and individuals who are allergic to aspirin may also react adversely to clopidogrel due to its mechanism of action. This risk of cross-reactivity is particularly relevant in patients with a history of aspirin-induced hypersensitivity, which can manifest as urticaria, angioedema, or even anaphylaxis. On the other hand, beta blockers, statins, and calcium channel blockers do not share this antiplatelet effect and do not trigger similar allergic reactions in patients who are sensitive to aspirin. Therefore, while they may be safe for use in this patient population, clopidogrel’s potential to cause similar side effects makes it risky for those with an aspirin allergy.